ABSTRACT
OBJECTIVE@#To determine the therapeutic effect of simvastatin combined with traditional medicine on patients with X-syndrome, and on the reserve of heart function and endothelial function.@*METHODS@#Forty patients with X-syndrome were recruited from September 2006 to September 2007 and randomly divided into 2 groups (a simvastatin group and a control group). The control group received routine treatment including beta receptor blocker, calcium-channel blocker (CCB) and long active nitrate. The simvastatin group received simvastatin and the routine treatment. The clinical condition and exercise test (TET) were performed before and after the treatment.The levels of triglyeride (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), endothelin-1 (ET-1) and nitric oxide (NO) were measured.@*RESULTS@#The frequencies of chest pain in the simvastatin group were lower than those in the control group. The levels of ET-1, ET-1/NO, TG, TC, and LDL-C were significantly decreased in the simvastatin group as compared with the control group after the treatment. The levels of HDL-C and NO were significantly increased in the simvastatin group as compared with the control group after the treatment. The time in TET was significantly increased in the simvastatin group as compared with the control group. The frequencies of chest pain were positively related to the level of ET-1/NO and negatively related to the time in TET.@*CONCLUSION@#Simvastatin is effective for patients with X-syndrome and may improve the endothelial function and the reserve of heart function.
Subject(s)
Female , Humans , Male , Anticholesteremic Agents , Therapeutic Uses , Cholesterol, HDL , Blood , Endothelin-1 , Blood , Endothelium, Vascular , Exercise Test , Microvascular Angina , Drug Therapy , Nitric Oxide , Blood , Simvastatin , Therapeutic UsesABSTRACT
OBJECTIVE@#To investigate cardiotrophin-1(CT-1) expression in the ventricle and the effects of angiotensin II type I receptor antagonist (AT(1)RA) irbesartan on the ventricular remodeling in adriamycin myocardiopathy.@*METHODS@#Thirty male SD rats were randomized into 2 groups: a control group (n=10) and a model group (n=20). The model group was administered adriamycin and 18 rats survived. And theses rats were randomized again into 2 groups. One was treated with irbesartan [50 mg/(kg x d), with stomach-tube], and the other received equal saline, so did the control group. After 12 weeks, the protein level of CT-1 was detected by immunohistochemistry.@*RESULTS@#Ventricular CT-1 in the model control group and the treatment group was higher than that in the control group and the correlation analysis showed that ventricular CT-1 of the model control group was positively correlated with the left ventricular weight index, and CT-1 of the treatment group was lower than that of the model control group.@*CONCLUSION@#CT-1 was assumed to take part in the ventricular remodeling. The mechanism of irbesartan on the ventricular remodeling may be related to the downregulation of CT-1 expression.
Subject(s)
Animals , Male , Rats , Angiotensin II Type 1 Receptor Blockers , Pharmacology , Biphenyl Compounds , Pharmacology , Cardiomyopathies , Metabolism , Cytokines , Metabolism , Doxorubicin , Irbesartan , Myocytes, Cardiac , Metabolism , Rats, Sprague-Dawley , Tetrazoles , Pharmacology , Ventricular RemodelingABSTRACT
OBJECTIVE@#To observe the efficacy of diet control and aerobic exercises on the patients with metabolic syndrome(MS).@*METHODS@#Sixty sedentary patients with MS were randomly divided into a diet control group, an aerobic exercise group, and a diet control combined with aerobic exercise group, each group with 20 persons. Patients in the simple diet control group ate a low-salt, low-cholesterol, low-calorie and high-cellulose diet; patients in the simple aerobic exercises group performed aerobic exercise 30 minutes every time, 3-5 times per week for 12 weeks; while patients in the combination therapy group performed aerobic exercises and diet control. Fasting serum insulin and free fatty acid (FFA) were measured by radio immunity and enzyme-colorimetric method. Serum leptin concentration was measured by enzyme linked immunosorbent assay (ELISA). Homeostasis model assessment (HOMA) insulin resistance index was calculated using the homeostasis model assessment equation. Twenty healthy subjects were selected as the control group.@*RESULTS@#Serum concentration of FFA, blood pressure, and leptin and insulin resistance index (IRI)of patients with MS significantly increased compared with those of the controls. After 12 weeks, IRI and body mass index (BMI)significantly decreased but blood fat and leptin did not change significantly in the diet control group. IRI and BMI significantly decreased, and triglyceride, FFA and leptin also significantly decreased in the combination therapy group.@*CONCLUSION@#Simple diet control and aerobic exercises are beneficial for patients with MS. It could significantly improve the effect of diet control combined with aerobic exercises on patients with metabolic syndrome.